Association between Serum Selenium Level and the Presence of Diabetes Mellitus: A Meta-Analysis of Observational Studies.

ABSTRACT: BACKGROUND:Epidemiological studies have suggested an association between selenium (Se) and diabetes mellitus (DM). However, different studies have reported conflicting results. Therefore, we performed a comprehensive meta-analysis to clarify the impact of Se on DM. METHODS:We searched the PubMed database for studies on the association between Se and DM from inception to June 2018. RESULTS:Twenty articles evaluating 47,930 participants were included in the analysis. The meta-analysis found that high levels of Se were significantly associated with the presence of DM (pooled odds ratios [ORs], 1.88; 95% confidence interval [CI], 1.44 to 2.45). However, significant heterogeneity was found (I²=82%). Subgroup analyses were performed based on the Se measurement methods used in each study. A signi

SUBMITTER: Kim J 

PROVIDER: S-EPMC6712224 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature