Gene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility.

ABSTRACT:

Background

Cytochrome P450 (CYPs) are heme proteins involved in the metabolism of a variety of endogenous and exogenous substances and play an important role in the carcinogenesis mechanisms of environmental and hereditary factors. The objective of this study was to investigate how polymorphisms of CYPs correlate with lung cancer (LC) susceptibility.

Methods

Six single nucleotide polymorphisms (SNPs) were genotyped in this study. The chi-square test and unconditional logistic regression model were used to evaluate the correlation between SNPs and LC susceptibility. The expressions and survival data of genes in patients with LC were mined using Oncomine and Kaplan-Meier Plotter database.

Results

Four SNPs were found to be significantly associated with the risk of LC de

SUBMITTER: Li M 

PROVIDER: S-EPMC6712450 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature