The interleukin-33 receptor contributes to pulmonary responses to ozone in male mice: role of the microbiome.

ABSTRACT:

Background

Interleukin-33 is released in the airways following acute ozone exposure and has the ability to cause airway hyperresponsiveness, a defining feature of asthma. Ozone causes greater airway hyperresponsiveness in male than female mice. Moreover, sex differences in the gut microbiome account for sex differences in this response to ozone. The purpose of this study was to determine whether there were sex differences in the role of interleukin-33 in ozone-induced airway hyperresponsiveness and to examine the role of the microbiome in these events.

Methods

Wildtype mice and mice genetically deficient in ST2, the interleukin-33 receptor, were housed from weaning with either other mice of the same genotype and sex, or with mice of the same sex but opposite genotype. At 15 

SUBMITTER: Kasahara DI 

PROVIDER: S-EPMC6712741 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature