Mutational concordance between primary and metastatic melanoma: a next-generation sequencing approach.

ABSTRACT:

Background

Cutaneous malignant melanoma (CMM) is one of the most common skin cancers worldwide. Limited information is available in the current scientific literature on the concordance of genetic alterations between primary and metastatic CMM. In the present study, we performed next-generation sequencing (NGS) analysis of the main genes participating in melanoma pathogenesis and progression, among paired primary and metastatic lesions of CMM patients, with the aim to evaluate levels of discrepancies in mutational patterns.

Methods

Paraffin-embedded tumor tissues of the paired lesions were retrieved from the archives of the institutions participating in the study. NGS was performed using a specific multiple-gene panel constructed by the Italian Melanoma Intergroup (IMI) to ex

SUBMITTER: Manca A 

PROVIDER: S-EPMC6712827 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature