Preliminary study on microR-148a and microR-10a in dermal papilla cells of Hu sheep.

ABSTRACT:

Background

Hu sheep, a unique Chinese breed with high reproductive performance, are also well known for their rare white lambskin in China. The quality of lambskin is affected by hair follicles, and dermal papilla cells are an important component of hair follicles that plays a key role in hair follicle growth and development. This study helps elucidate the effect of miR-148a and miR-10a on hair follicle growth and development.

Results

Based on the results of gene chip and high-throughput sequencing, bone morphogenetic protein 7 (BMP7) was used as a research object. Bioinformatics analysis and the dual-luciferase reporter system indicated that, along with Western blot and quantitative real-time polymerase chain reaction (qRT-PCR) that miR-148a and miR-10a target relationships

SUBMITTER: Lv X 

PROVIDER: S-EPMC6712829 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature