Potential early clinical stage colorectal cancer diagnosis using a proteomics blood test panel.

ABSTRACT:

Background

One of the most significant challenges in colorectal cancer (CRC) management is the use of compliant early stage population-based diagnostic tests as adjuncts to confirmatory colonoscopy. Despite the near curative nature of early clinical stage surgical resection, mortality remains unacceptably high-as the majority of patients diagnosed by faecal haemoglobin followed by colonoscopy occur at latter stages. Additionally, current population-based screens reliant on fecal occult blood test (FOBT) have low compliance (~ 40%) and tests suffer low sensitivities. Therefore, blood-based diagnostic tests offer survival benefits from their higher compliance (≥ 97%), if they can at least match the sensitivity and specificity of FOBTs. However, discovery of low abundance plasma bioma

SUBMITTER: Ahn SB 

PROVIDER: S-EPMC6712843 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature