Improved homology modeling of the human & rat EP₄ prostanoid receptors.

ABSTRACT:

Background

The EP₄ prostanoid receptor is one of four GPCRs that mediate the diverse actions of prostaglandin E₂ (PGE₂). Novel selective EP₄ receptor agonists would assist to further elucidate receptor sub-type function and promote development of therapeutics for bone healing, heart failure, and other receptor associated conditions. The rat EP₄ (rEP₄) receptor has been used as a surrogate for the human EP₄ (hEP₄) receptor in multiple SAR studies. To better understand the validity of this traditional approach, homology models were generated by threading for both receptors using the RaptorX server. These models were fit to an implicit membrane using the PPM server and OPM database with refinement

SUBMITTER: Holt MC 

PROVIDER: S-EPMC6712885 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature