A systematic summary and comparison of animal models for chemotherapy induced (peripheral) neuropathy (CIPN).

ABSTRACT: Despite the large amount of human and experimental studies no effective (prophylactic) treatment exists for chemotherapy induced peripheral neuropathy (CIPN), a disabling side effect of many cancer treatments. One of the underlying reasons for this could be that often the preclinical animal models used are not the best representation of the clinical situation. We therefore present a systematic summary and comparison of all animal models currently described in literature for CIPN focusing on stimulus evoked pain-like behaviour and neurophysiological alterations in nerve function (650 included papers, and a comparison of 183 models), that resulted in a clear overview of the most effective and robust CIPN models using an administration route used in clinical practice. Using our three-step app

SUBMITTER: Gadgil S 

PROVIDER: S-EPMC6713358 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature