Axonal sprouting in the dorsal cochlear nucleus affects gap‑prepulse inhibition following noise exposure.

ABSTRACT: One of the primary theories of the pathogenesis of tinnitus involves maladaptive auditory‑somatosensory plasticity in the dorsal cochlear nucleus (DCN), which is assumed to be due to axonal sprouting. Although a disrupted balance between auditory and somatosensory inputs may occur following hearing damage and may induce tinnitus, examination of this phenomenon employed a model of hearing damage that does not account for the causal relationship between these changes and tinnitus. The present study aimed to investigate changes in auditory‑somatosensory innervation and the role that axonal sprouting serves in this process by comparing results between animals with and without tinnitus. Rats were exposed to a noise‑inducing temporary threshold shift and were subsequently divided into tinnitus a

SUBMITTER: Han KH 

PROVIDER: S-EPMC6713418 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature