Temporal Characterization of Neuronal Migration Behavior on Chemically Patterned Neuronal Circuits in a Defined in Vitro Environment.

ABSTRACT: Directed control of neuronal migration, facilitating the correct spatial positioning of neurons, is crucial to the development of a functional nervous system. An understanding of neuronal migration and positioning on patterned surfaces in vitro would also be beneficial for investigators seeking to design culture platforms capable of mimicking the complex functional architectures of neuronal tissues for drug development as well as basic biomedical research applications. This study used coplanar self-assembled monolayer patterns of cytophilic, N-1[3-(trimethoxysilyly)propyl] diethylenetriamine (DETA) and cytophobic, tridecafluoro-1,1,2,2-tetrahydrooctyl-1-trichlorosilane (13F) to assess the migratory behavior and physiological characteristics of cultured neurons. Analysis of ti

SUBMITTER: Natarajan A 

PROVIDER: S-EPMC6713422 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature