Aggrecan nanoscale solid-fluid interactions are a primary determinant of cartilage dynamic mechanical properties.

ABSTRACT: Poroelastic interactions between interstitial fluid and the extracellular matrix of connective tissues are critical to biological and pathophysiological functions involving solute transport, energy dissipation, self-stiffening and lubrication. However, the molecular origins of poroelasticity at the nanoscale are largely unknown. Here, the broad-spectrum dynamic nanomechanical behavior of cartilage aggrecan monolayer is revealed for the first time, including the equilibrium and instantaneous moduli and the peak in the phase angle of the complex modulus. By performing a length scale study and comparing the experimental results to theoretical predictions, we confirm that the mechanism underlying the observed dynamic nanomechanics is due to solid-fluid interactions (poroelasticity) at the mole

SUBMITTER: Nia HT 

PROVIDER: S-EPMC6713486 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature