Dataset Information

Birth weight discordance in very low birth weight twins: mortality, morbidity, and neurodevelopment.

ABSTRACT:

Objective

Examine outcomes among birth weight concordant and discordant 401-1500 g twins.

Study design

Twins (n = 8,114) at NICHD Neonatal Research Network (1994-2011) were studied. Discordance (birth weight difference/larger twin birth weight x 100%) was categorized into: ≤ 14, > 14-20, > 20-30, and > 30%. Separate logistic regression models for the smaller and larger infants assessed the adjusted association between discordance and outcomes.

Results

Compared with the smaller twin with ≤ 14% discordance, mortality, necrotizing enterocolitis, severe retinopathy of prematurity, bronchopulmonary dysplasia, and neurodevelopmental impairment or death were highest among the smaller twins with discordance > 30%. The larger twins with discordance > 30% had higher odds of patent ductus arteriosus, moderate-to-severe cerebral palsy, blindness, cognitive and motor scores < 70. Odds of cerebral palsy and blindness were also higher among the larger twins with discordance > 14-20%.

Conclusions

Discordance > 30% was associated with higher mortality in the smaller twin and higher morbidities among the smaller and larger twins.

SUBMITTER: Boghossian NS

PROVIDER: S-EPMC6713585 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Publications

Birth weight discordance in very low birth weight twins: mortality, morbidity, and neurodevelopment.

Boghossian Nansi S NS Saha Shampa S Bell Edward F EF Brumbaugh Jane E JE Shankaran Seetha S Carlo Waldemar A WA Das Abhik A

Journal of perinatology : official journal of the California Perinatal Association 20190716 9

<h4>Objective</h4>Examine outcomes among birth weight concordant and discordant 401-1500 g twins.<h4>Study design</h4>Twins (n = 8,114) at NICHD Neonatal Research Network (1994-2011) were studied. Discordance (birth weight difference/larger twin birth weight x 100%) was categorized into: ≤ 14, > 14-20, > 20-30, and > 30%. Separate logistic regression models for the smaller and larger infants assessed the adjusted association between discordance and outcomes.<h4>Results</h4>Compared with the smal ...[more]

PMID: 31312035

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Dataset Information

Birth weight discordance in very low birth weight twins: mortality, morbidity, and neurodevelopment.

Objective

Study design

Results

Conclusions

Publications

Birth weight discordance in very low birth weight twins: mortality, morbidity, and neurodevelopment.

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