The genetic relationship between educational attainment and cognitive performance in major psychiatric disorders.

ABSTRACT: Cognitive deficits are a core feature of psychiatric disorders like schizophrenia and bipolar disorder. Evidence supports a genome-wide polygenic score (GPS) for educational attainment (GPS_EDU) can be used to explain variability in cognitive performance. We aimed to identify different cognitive domains associated with GPS_EDU in a transdiagnostic clinical cohort of chronic psychiatric patients with known cognitive deficits. Bipolar and schizophrenia patients from the PsyCourse cohort (N = 730; 43% female) were used. Likewise, we tested whether GPSs for schizophrenia (GPS_SZ) and bipolar disorder (GPS_BD) were associated with cognitive outcomes. GPS_EDU explained 1.5% of variance in the backward verbal digit span, 1.9% in the number of corr

SUBMITTER: Comes AL 

PROVIDER: S-EPMC6713703 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature