3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles.

ABSTRACT: The aim of this study was to explore the feasibility of using different 3D printed internal geometries as tablet formulations to obtain controlled release profiles. In order to obtain controllable release profiles, three types of tablet models (Cylinder, Horn and Reversed Horn) with controlled structures were designed. The cylinder model shows a constant release profile and can keep the drug concentration within a certain range. The horn model exhibits an increasing release profile, which is suitable for the patients who have the drug resistance in the course of medication. The reversed horn model has a decreasing release profile that would be applied to hypertension cure. Furthermore, three types of tablets were fabricated successfully by a fused deposition modeling three-dimensional (3D)

SUBMITTER: Xu X 

PROVIDER: S-EPMC6713737 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature