White matter alterations in early-stage Alzheimer's disease: A tract-specific study.

ABSTRACT:

Introduction

Diffusion magnetic resonance imaging may allow for microscopic characterization of white matter degeneration in early stages of Alzheimer's disease.

Methods

Multishell Diffusion magnetic resonance imaging data were acquired from 100 participants (40 cognitively normal, 38 with subjective cognitive decline, and 22 with mild cognitive impairment [MCI]). White matter microscopic degeneration in 27 major tracts of interest was assessed using diffusion tensor imaging (DTI), neurite orientation dispersion and density imaging, and q-space imaging.

Results

Lower DTI fractional anisotropy and higher radial diffusivity were observed in the cingulum, thalamic radiation, and forceps major of participants with MCI. These tracts of interest also had the highest predict

SUBMITTER: Wen Q 

PROVIDER: S-EPMC6713788 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature