RECK in Neural Precursor Cells Plays a Critical Role in Mouse Forebrain Angiogenesis.
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ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC6713797 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
RECK in Neural Precursor Cells Plays a Critical Role in Mouse Forebrain Angiogenesis.
Li Huiping H Miki Takao T Almeida Glícia Maria de GM Hanashima Carina C Matsuzaki Tomoko T Kuo Calvin J CJ Watanabe Naoki N Noda Makoto M
iScience 20190808
RECK in neural precursor cells (NPCs) was previously found to support Notch-dependent neurogenesis in mice. On the other hand, recent studies implicate RECK in endothelial cells (ECs) in WNT7-triggered canonical WNT signaling essential for brain angiogenesis. Here we report that RECK in NPCs is also critical for brain angiogenesis. When Reck is inactivated in Foxg1-positive NPCs, mice die shortly after birth with hemorrhage in the forebrain, with angiogenic sprouts stalling at the periphery and ...[more]
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