Dynamic colloidal nanoparticle assembly triggered by aptamer-receptor interactions on live cell membranes.

ABSTRACT: Cells use dynamic systems such as enzyme cascades and signaling networks to control cellular functions. Synthetic dynamic systems that can be target-responsive have great potential to be applied for biomedical applications but the operation of such dynamic systems in complex cellular environments remains challenging. Here, we engineered an aptamer and DNA displacement reaction-based dynamic system that can transform its nanostructure in response to the epithelial cell adhesion molecule (EpCAM) on live cell membranes. The dynamic system consisted of a core nanoparticle and small satellite nanoparticles. With the modifications of different DNA hairpin strands and swing arm strands partially hybridized with an aptamer that specifically recognizes the EpCAM, the two separated particles can dyn

SUBMITTER: Yang L 

PROVIDER: S-EPMC6713859 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature