Rhodium catalyzed template-assisted distal para-C-H olefination.

ABSTRACT: Rhodium catalysis has been extensively used for ortho-C-H functionalization reactions, and successfully extended to meta-C-H functionalization. Its application to para-C-H activation remains an unmet challenge. Herein we disclose the first example of such a reaction, with the Rh-catalyzed para-C-H olefination of arenes. The use of a Si-linked cyanobiphenyl unit as a traceless directing group leads to highly para-selective arene-olefin couplings.

SUBMITTER: Dutta U 

PROVIDER: S-EPMC6713868 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature