There Is Something Fishy About Liver Cancer: Zebrafish Models of Hepatocellular Carcinoma.

ABSTRACT: The incidence of hepatocellular carcinoma (HCC) and the mortality resulting from HCC are both increasing. Most patients with HCC are diagnosed at advanced stages when curative treatments are impossible. Current drug therapy extends mean overall survival by only a short period of time. Genetic mutations associated with HCC vary widely. Therefore, transgenic and mutant animal models are needed to investigate the molecular effects of specific mutations, classify them as drivers or passengers, and develop targeted treatments. Cirrhosis, however, is the premalignant state common to 90% of HCC patients. Currently, no specific therapies are available to halt or reverse the progression of cirrhosis to HCC. Understanding the genetic drivers of HCC as well as the biochemical, mechanical, hormonal, a

SUBMITTER: Wrighton PJ 

PROVIDER: S-EPMC6713889 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature