Do Genetic Susceptibility Variants Associate with Disease Severity in Early Active Rheumatoid Arthritis?

ABSTRACT:

Objective

Genetic variants affect both the development and severity of rheumatoid arthritis (RA). Recent studies have expanded the number of RA susceptibility variants. We tested the hypothesis that these associated with disease severity in a clinical trial cohort of patients with early, active RA.

Methods

We evaluated 524 patients with RA enrolled in the Combination Anti-Rheumatic Drugs in Early RA (CARDERA) trials. We tested validated susceptibility variants - 69 single-nucleotide polymorphisms (SNP), 15 HLA-DRB1 alleles, and amino acid polymorphisms in 6 HLA molecule positions - for their associations with progression in Larsen scoring, 28-joint Disease Activity Scores, and Health Assessment Questionnaire (HAQ) scores over 2 years using linear mixed-effects and latent gro

SUBMITTER: Scott IC 

PROVIDER: S-EPMC6714044 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature