The Akt/FoxO/p27^Kip1 axis contributes to the anti-proliferation of pentoxifylline in hypertrophic scars.

ABSTRACT: Hypertrophic scars (HS) are characterized by the excessive production and deposition of extracellular matrix (ECM) proteins. Pentoxifylline (PTX), a xanthine derived antioxidant, inhibits the proliferation, inflammation and ECM accumulation of HS. In this study, we aimed to explore the effect of PTX on HS and further clarify the mechanism of PTX-induced anti-proliferation. We found that PTX could significantly attenuate proliferation of HS fibroblasts and fibrosis in an animal HS model. PTX inhibited the proliferation of HSFs in a dose- and time-dependent manner, and this growth inhibition was mainly mediated by cell cycle arrest. Transcriptome sequencing showed that PTX affects HS formation through the PI3K/Akt/FoxO1 signalling pathway to activate p27^Kip1 . PTX down-regulated p

SUBMITTER: Yang F 

PROVIDER: S-EPMC6714140 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature