Zingerone attenuates aortic banding-induced cardiac remodelling via activating the eNOS/Nrf2 pathway.

ABSTRACT: Cardiac remodelling refers to a series of changes in the size, shape, wall thickness and tissue structure of the ventricle because of myocardial injury or increased pressure load. Studies have shown that cardiac remodelling plays a significant role in the development of heart failure. Zingerone, a monomer component extracted from ginger, has been proven to possess various properties including antioxidant, anti-inflammatory, anticancer and antidiabetic properties. As oxidative stress and inflammation contribute to acute and chronic myocardial injury, we explored the role of zingerone in cardiac remodelling. Mice were subjected to aortic banding (AB) or sham surgery and then received intragastric administration of zingerone or saline for 25 days. In vitro, neonatal rat cardiomyocytes (NRCMs)

SUBMITTER: Liu C 

PROVIDER: S-EPMC6714175 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature