Safety of direct oral anticoagulants in patients with hereditary hemorrhagic telangiectasia.

ABSTRACT:

Background

Hereditary hemorrhagic telangiectasia (HHT) is a rare vascular dysplasia resulting in visceral arteriovenous malformations and smaller mucocutaneous telangiectasia. Most patients experience recurrent nosebleeds and become anemic without iron supplementation. However, thousands may require anticoagulation for conditions such as venous thromboembolism and/or atrial fibrillation. Over decades, tolerance data has been published for almost 200 HHT-affected users of warfarin and heparins, but there are no published data for the newer direct oral anticoagulants (DOACs) in HHT.

Methods

To provide such data, a retrospective audit was conducted across the eight HHT centres of the European Reference Network for Rare Multisystemic Vascular Diseases (VASCERN), in Denmark, Fran

SUBMITTER: Shovlin CL 

PROVIDER: S-EPMC6714298 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature