Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma.

ABSTRACT:

Background

Gradual loss of terminal differentiation markers and gain of stem cell-like properties is a major hall mark of cancer malignant progression. The stem cell pluripotent transcriptional factor SOX family play critical roles in governing tumor plasticity and lineage specification. This study aims to establish a novel SOX signature to monitor the extent of tumor dedifferentiation and predict prognostic significance in hepatocellular carcinoma (HCC).

Methods

The RNA-seq data from The Cancer Genome Atlas (TCGA) LIHC project were chronologically divided into the training (n = 188) and testing cohort (n = 189). LIRI-JP project from International Cancer Genome Consortium (ICGC) data portal was used as an independent validation cohort (n = 232). Kaplan-Meier and multivariabl

SUBMITTER: Li MM 

PROVIDER: S-EPMC6714407 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature