Deletion at 2q14.3 is associated with worse response to TNF-α blockers in patients with rheumatoid arthritis.

ABSTRACT:

Background

Structural variations such as copy number variations (CNVs) have a functional impact on various human traits. This study profiled genome-wide CNVs in Korean patients with rheumatoid arthritis (RA) to investigate the efficacy of treatment with TNF-α blockers.

Methods

A total of 357 Korean patients with RA were examined for the efficacy of TNF-α blocker treatment. Disease activity indexes were measured at baseline and 6 months after the treatment. The patients were classified as responders and non-responders based on the change in disease activity indexes according to the EULAR response criteria. CNVs in the same patients were profiled using fluorescence signal intensity data generated by a genome-wide SNP array. The association of CNVs with response to TNF-α blocke

SUBMITTER: Gu KN 

PROVIDER: S-EPMC6714408 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature