WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling.

ABSTRACT:

Background

Breast cancer is the leading cause of cancer-related death in women worldwide. Metastatic disease remains the primary cause of death in patients with breast cancer. Basal-like breast cancer (BLBC) is associated with aggressive behavior, stem-like phenotype, high histological grade, poor clinical features, and high rates of recurrences and/or metastasis. However, the mechanism of BLBC phenotype shaping remains obscure.

Methods

Seventeen normal breast/breast cancer cell lines were used for evaluating the breast cancer subtype-markers, WNT targets and constitutive components, and epithelial mesenchymal transition (EMT) markers analysis by western blot. One hundred and twenty formalin-fixed breast cancer tissues were used for immunohistochemistry (IHC) staining. Nine

SUBMITTER: Jiang S 

PROVIDER: S-EPMC6714433 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature