Three miRNAs cooperate with host genes involved in human cardiovascular disease.

ABSTRACT:

Background

Understanding the roles of miRNAs in cardiovascular disease remains a challenge. Genomic linkage indicates a functional relationship between intronic miRNAs and their host genes. However, few studies have shown functional association between intronic miRNAs and their host coding genes that are genetically associated with cardiovascular disease.

Methods

In this study, we investigated functional relationship between three protein-coding genes genetically associated with cardiovascular disease, i.e., CDH13, SLC12A3, and CKAP5, and their intronic miRNAs using a data-driven approach.

Results

We found that the three protein-coding genes functionally interact with targets of their intronic miRNAs, i.e., miR-3182, miR-6863, and miR-5582, in a tissue-specific patter

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC6714460 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature