A prospective comparison of conventional cytology and digital image analysis for the identification of pancreatic malignancy in patients undergoing EUS-FNA.

ABSTRACT:

Background and objectives

Digital image analysis (DIA) has been reported to be a sensitive method to detect pancreatic neoplasms by assessing nuclear DNA content. The aim of the current study was to evaluate the diagnostic performance of DIA for pancreatic malignancy relative to conventional cytology (CC) in patients undergoing EUS-FNA.

Patients and methods

One hundred and forty-two patients with suspected pancreatic malignancy were enrolled prospectively in this study. FNA sample from each patient was evenly divided and assessed by CC and DIA. Findings from histopathology of FNA specimens and a minimum 12-month follow-up were used as the standard.

Results

Total 102 out of 142 patients were determined as pancreatic cancer (PC) in this study. The overall sensitivity, s

SUBMITTER: Kong F 

PROVIDER: S-EPMC6714483 | biostudies-literature | 2019 Jul-Aug

REPOSITORIES: biostudies-literature