Hepatic Bioactivation of Skin-Sensitizing Drugs to Immunogenic Reactive Metabolites.

ABSTRACT: The clinical use of some drugs, such as carbamazepine, phenytoin, and allopurinol, is often associated with adverse cutaneous reactions. The bioactivation of drugs into immunologically reactive metabolites by the liver is postulated to be the first step in initiating a downstream cascade of pathological immune responses. Current mechanistic understanding and the ability to predict such adverse drug cutaneous responses have been partly limited by the lack of appropriate cutaneous drug bioactivation experimental models. Although in vitro human liver models have been extensively investigated for predicting hepatotoxicity and drug-drug interactions, their ability to model the generation of antigenic reactive drug metabolites that are capable of eliciting immunological reactions is not well und

SUBMITTER: Chong LH 

PROVIDER: S-EPMC6714514 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature