Bioinformatic and Molecular Analysis of Inverse Autotransporters from Escherichia coli.

ABSTRACT: Proteins secreted by the type V secretion system possess multiple functions, including the capacity to mediate adhesion, aggregation, and biolfilm formation. The type V secretion system can be divided into five subclasses, one of which is the type Ve system. Proteins of the type Ve secretion system are also referred to as inverse autotransporters (IATs). In this study, we performed an in silico analysis of 126 completely sequenced Escherichia coli genomes available in the NCBI database and identified several distinct IAT-encoding gene families whose distribution varied throughout the E. coli phylogeny. The genes included three characterized IATs (intimin, fdeC, and yeeJ) and four uncharacterized IATs (here named iatA, iatB, iatC, and

SUBMITTER: Goh KGK 

PROVIDER: S-EPMC6714894 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature