The RIPper, a web-based tool for genome-wide quantification of Repeat-Induced Point (RIP) mutations.

ABSTRACT:

Background

The RIPper (http://theripper.hawk.rocks) is a set of web-based tools designed for analyses of Repeat-Induced Point (RIP) mutations in the genome sequences of Ascomycota. The RIP pathway is a fungal genome defense mechanism that is aimed at identifying repeated and duplicated motifs, into which it then introduces cytosine to thymine transition mutations. RIP thus serves to deactivate and counteract the deleterious consequences of selfish or mobile DNA elements in fungal genomes. The occurrence, genetic context and frequency of RIP mutations are widely used to assess the activity of this pathway in genomic regions of interest. Here, we present a bioinformatics tool that is specifically fashioned to automate the investigation of changes in RIP product and substrate nucleoti

SUBMITTER: van Wyk S 

PROVIDER: S-EPMC6714961 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature