Arginine vasopressin in cerebrospinal fluid is a marker of sociality in nonhuman primates.

ABSTRACT: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by core social impairments. ASD remains poorly understood because of the difficulty in studying disease biology directly in patients and the reliance on mouse models that lack clinically relevant, complex social cognition abilities. We use ethological observations in rhesus macaques to identify male monkeys with naturally occurring low sociality. These monkeys showed differences in specific neuropeptide and kinase signaling pathways compared to socially competent male monkeys. Using a discovery and replication design, we identified arginine vasopressin (AVP) in cerebrospinal fluid (CSF) as a key marker of group differences in monkey sociality; we replicated these findings in an independent monkey cohort. We also

SUBMITTER: Parker KJ 

PROVIDER: S-EPMC6714978 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature