Comparison of Low-Molecular-Weight Heparins Prepared From Ovine Heparins With Enoxaparin.

ABSTRACT: Heparin and its low-molecular-weight heparin derivatives are widely used clinical anticoagulants. These drugs are critical for the practice of medicine in applications, including kidney dialysis, cardiopulmonary bypass, and in the management of venous thromboembolism. Currently, these drugs are derived from livestock, primarily porcine intestine and less frequently bovine intestine and bovine lung. The worldwide dependence on the pig as a single dominant animal species has made the supply chain for this critical drug quite fragile, leading to the search for other sources of these drugs, including the expanded use of bovine tissues. A number of laboratories are now also examining the similarities between heparin and low-molecular-weight heparins prepared from porcine and ovine tissues. This

SUBMITTER: Chen J 

PROVIDER: S-EPMC6714994 | biostudies-literature | 2019 Jan-Dec

REPOSITORIES: biostudies-literature