Stereotyped high-frequency oscillations discriminate seizure onset zones and critical functional cortex in focal epilepsy.

ABSTRACT: High-frequency oscillations in local field potentials recorded with intracranial EEG are putative biomarkers of seizure onset zones in epileptic brain. However, localized 80-500 Hz oscillations can also be recorded from normal and non-epileptic cerebral structures. When defined only by rate or frequency, physiological high-frequency oscillations are indistinguishable from pathological ones, which limit their application in epilepsy presurgical planning. We hypothesized that pathological high-frequency oscillations occur in a repetitive fashion with a similar waveform morphology that specifically indicates seizure onset zones. We investigated the waveform patterns of automatically detected high-frequency oscillations in 13 epilepsy patients and five control subjects, with an average of 73 s

SUBMITTER: Liu S 

PROVIDER: S-EPMC6715109 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature