Cognitive function in multiple sclerosis: A long-term look on the bright side.

ABSTRACT:

Background

Multiple sclerosis (MS) may lead to cognitive decline over-time.

Objectives

Characterize cognitive performance in MS patients with long disease duration treated with disease modifying drugs (DMD) in relation to disability and determine the prevalence of cognitive resilience.

Methods

Cognitive and functional outcomes were assessed in 1010 DMD-treated MS patients at least 10 years from onset. Cognitive performance was categorized as high, moderate or low, and neurological disability was classified according to the Expanded Disability Status Scale (EDSS) as mild, moderate or severe. Relationship between cognitive performance and disability was examined.

Results

After a mean disease duration of 19.6 (SD = 7.7) years, low cognitive performance was observe

SUBMITTER: Harel Y 

PROVIDER: S-EPMC6715181 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature