Fatty liver index is a strong predictor of changes in glycemic status in people with prediabetes: The IT-DIAB study.

ABSTRACT:

Background & aims

In patients at metabolic risk, nonalcoholic fatty liver disease is a strong and highly prevalent predictor for type 2 diabetes. Its assessment in clinical practice is not easy but the fatty liver index (FLI) could be used as a surrogate. Here, we studied the association between the FLI and the conversion to new-onset diabetes (NOD) or prediabetes reversion in patients with prediabetes.

Methods

The IT-DIAB observational study included 389 individuals with prediabetes, defined as fasting plasma glucose (FPG) between 110 and 125 mg/dL. NOD conversion was defined as a first FPG value ≥ 126 mg/dL and prediabetes reversion as a first FPG value < 110 mg/dL. The associations of both events with baseline FLI were studied separately using multivariate Cox models.

SUBMITTER: Wargny M 

PROVIDER: S-EPMC6715190 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature