Kinetics of the soluble urokinase plasminogen activator receptor (suPAR) in cirrhosis.

ABSTRACT:

Background

The soluble urokinase plasminogen activator receptor (suPAR) is related to hepatic inflammation and fibrosis and has been suggested to participate in the development of liver cirrhosis. Therefore, the aim of the current study was to measure the concentration of suPAR in the hepatic vein of cirrhotic patients during a liver vein catheterization to identify a possible hepatic suPAR generation. Furthermore, we explored if suPAR levels were associated with the degree of cirrhosis and liver dysfunction.

Methods and patients

We included 105 cirrhotic patients and 19 liver-healthy controls. Blood was sampled from the hepatic vein and the femoral artery and suPAR was measured by enzyme-linked immunosorbent assay.

Results

We identified significantly higher median su

SUBMITTER: Garnæs E 

PROVIDER: S-EPMC6715219 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature