Treatment sequences for advanced renal cell carcinoma: A health economic assessment.

ABSTRACT:

Objective

Advanced renal cell carcinoma (RCC) is commonly treated with vascular endothelial growth factor or mammalian target of rapamycin inhibitors. As new therapies emerge, interest grows in gaining a deeper understanding of treatment sequences. Recently, we developed a patient-level, discretely integrated condition event (DICE) simulation to estimate survival and lifetime costs for various cancer therapies, using a US payer perspective. Using this model, we explored the impact of treatments such as nivolumab and cabozantinib, and compared the clinical outcomes and cost consequences of commonly used treatment algorithms for patients with advanced RCC.

Methods

Included treatment sequences were pazopanib or sunitinib as first-line treatment, followed by nivolumab, cabozanti

SUBMITTER: Deniz B 

PROVIDER: S-EPMC6715231 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature