Prenatal antibiotics exposure and the risk of autism spectrum disorders: A population-based cohort study.

ABSTRACT:

Background

Prenatal antibiotic exposure induces changes in infants' gut microbiota composition and is suggested as a possible contributor in the development of autism spectrum disorders (ASD). In this study, we examined the association between prenatal antibiotic exposure and the risk of ASD.

Methods

This was a population-based cohort study utilizing the Manitoba Population Research Data Repository. The cohort included 214 834 children born in Manitoba, Canada between April 1, 1998 and March 31, 2016. Exposure was defined as having filled one or more antibiotic prescription during pregnancy. The outcome was autism spectrum disorder diagnosis. Multivariable Cox proportional hazards regression was used to estimate the risk of developing ASD in the overall cohort and in a sibli

SUBMITTER: Hamad AF 

PROVIDER: S-EPMC6715235 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature