Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis.

ABSTRACT: The granulomatous lesion resulting from infection with the fungus Paracoccidioides brasiliensis is characterized by a compact aggregate of mature cells, surrounded by a fibroblast- and collagen-rich content. Granuloma formation requires signaling elicited by inflammatory molecules such as members of the interleukin-1 family. Two members of this family have been thoroughly studied, namely IL-1α and IL-1β. In this study, we addressed the mechanisms underlying IL-1α secretion and its functional role on the host resistance to fungal infection. We found that, the expression of caspase-11 triggered by P. brasiliensis infection of macrophages depends on IFN-β production, because its inhibition reduced procaspase-11 levels. Curiously, caspase-11 deficiency did not impair IL-1β production, however

SUBMITTER: Ketelut-Carneiro N 

PROVIDER: S-EPMC6715237 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature