Association between leukocyte telomere length and the risk of pancreatic cancer: Findings from a prospective study.

ABSTRACT:

Introduction

Telomeres and telomerase play important role in maintaining chromosome integrity and genomic stability. Recent epidemiologic data showed inconsistent findings which suggested that both short and long leukocyte telomeres could be associated with increased risk of pancreatic cancer. We prospectively examined the association between telomere length and pancreatic cancer risk in a population-based cohort study.

Methods

The Singapore Chinese Health Study recruited 63,257 Chinese aged 45 to 74 years from 1993 to 1998 in Singapore. Relative telomere length in peripheral blood leukocytes was quantified using a validated monochrome multiplex quantitative polymerase chain reaction method in 26,540 participants, including 116 participants who later developed pancreatic can

SUBMITTER: Luu HN 

PROVIDER: S-EPMC6715276 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature