Ontology highlight
ABSTRACT:
SUBMITTER: Tomassoni-Ardori F
PROVIDER: S-EPMC6715404 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
eLife 20190820
Brain-derived neurotrophic factor (BDNF) is a potent modulator of brain synaptic plasticity. Signaling defects caused by dysregulation of its Ntrk2 (TrkB) kinase (TrkB.FL) and truncated receptors (TrkB.T1) have been linked to the pathophysiology of several neurological and neurodegenerative disorders. We found that upregulation of Rbfox1, an RNA binding protein associated with intellectual disability, epilepsy and autism, increases selectively hippocampal TrkB.T1 isoform expression. Physiologica ...[more]