CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells.

ABSTRACT:

Background

While the human fetal immune system defaults to a program of tolerance, there is concurrent need for protective immunity to meet the antigenic challenges encountered after birth. Activation of T cells in utero is associated with the fetal inflammatory response with broad implications for the health of the fetus and of the pregnancy. However, the characteristics of the fetal effector T cells that contribute to this process are largely unknown.

Methods

We analyzed primary human fetal lymphoid and mucosal tissues and performed phenotypic, functional, and transcriptional analysis to identify T cells with pro-inflammatory potential. The frequency and function of fetal-specific effector T cells was assessed in the cord blood of infants with localized and systemic inflam

SUBMITTER: Halkias J 

PROVIDER: S-EPMC6715406 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature