MRI Evidence of Altered Callosal Sodium in Mild Traumatic Brain Injury.

ABSTRACT:

Background and purpose

Mild traumatic brain injury is a leading cause of death and disability worldwide with 42 million cases reported annually, increasing the need to understand the underlying pathophysiology because this could help guide the development of targeted therapy. White matter, particularly the corpus callosum, is susceptible to injury. Animal models suggest stretch-induced mechanoporation of the axonal membrane resulting in ionic shifts and altered sodium ion distribution. The purpose of this study was to compare the distribution of total sodium concentration in the corpus callosum between patients with mild traumatic brain injury and controls using sodium (²³Na) MR imaging.

Materials and methods

Eleven patients with a history of mild traumatic brain

SUBMITTER: Grover H 

PROVIDER: S-EPMC6715457 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature