Comparative effectiveness of teriflunomide vs dimethyl fumarate in multiple sclerosis.

ABSTRACT:

Objective

In this study, we compared the effectiveness of teriflunomide (TRF) and dimethyl fumarate (DMF) on both clinical and MRI outcomes in patients followed prospectively in the Observatoire Français de la Sclérose en Plaques.

Methods

A total of 1,770 patients with relapsing-remitting multiple sclerosis (RRMS) (713 on TRF and 1,057 on DMF) with an available baseline brain MRI were included in intention to treat. The 1- and 2-year postinitiation outcomes were relapses, increase of T2 lesions, increase in Expanded Disability Status Scale score, and reason for treatment discontinuation. Propensity scores (inverse probability weighting) and logistic regressions were estimated.

Results

The confounder-adjusted proportions of patients were similar in TRF- compared to DMF

SUBMITTER: Laplaud DA 

PROVIDER: S-EPMC6715507 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature