Ontology highlight
ABSTRACT:
SUBMITTER: Yoneshiro T
PROVIDER: S-EPMC6715529 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Nature 20190821 7771
Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulating levels of BCAA are linked to obesity and diabetes. The mechanisms of this paradox remain unclear. Here we report that, on cold exposure, brown adipose tissue (BAT) actively utilizes BCAA in the mitochondria for thermogenesis and promotes systemic BCAA clearance in mice and humans. In turn, a BAT-specific defect in BCAA catabolism attenuates sy ...[more]