Cerebellar injury and impaired function in a rabbit model of maternal inflammation induced neonatal brain injury.

ABSTRACT: Cerebellum is involved in higher cognitive functions and plays important roles in neurological disorders. Cerebellar injury has been detected frequently in patients with preterm birth resulting in cognitive dysfunction later in life. Maternal infection and inflammation is associated with preterm birth and in neonatal brain injury. We have previously shown that intrauterine lipopolysaccharide (LPS) exposure induces white matter injury and microglial activation in the cerebral white matter tracts of neonatal rabbits, resulting in motor deficits consistent with the clinical findings of cerebral palsy (CP). Here we investigated whether intrauterine LPS exposure induced cerebellar inflammation and functional impairment. Timed-pregnant New Zealand white rabbits underwent a laparotomy on gestatio

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC6715541 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature