Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets.

ABSTRACT: One of the largest unmet medical needs is a disease-modifying treatment for Alzheimer's disease (AD). Recently, the role of microglia in disease, particularly AD, has gained great interest, following the identification of several disease risk-associated genes that are highly expressed in microglia. Microglia play a critical homeostatic role in the brain, with neuroinflammatory and phagocytic mechanisms being of particular importance. Here, we review the role of NLRP3, the complement system, and the triggering receptor expressed in myeloid cells 2 (TREM2) in modulating microglial functions. We have reviewed the targets, their molecular pathways and the therapeutic interventions aimed at modulating these targets, in the hope of discovering a novel therapeutic approach for the treatment of AD

SUBMITTER: Nizami S 

PROVIDER: S-EPMC6715590 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature