Neutralization of IL-17 rescues amyloid-β-induced neuroinflammation and memory impairment.

ABSTRACT:

Background and purpose

Alzheimer's disease (AD) is a common neurodegenerative disease characterized by a neuroinflammatory state, and to date, there is no cure and its treatment represents a large unmet clinical need. The involvement of Th17 cells in the pathogenesis of AD-related neuroinflammation has been reported in several studies. However, the role of the cytokine, IL-17 has not been well addressed. Herein, we investigate the effects of IL-17 neutralizing antibody (IL-17Ab) injected by i.c.v. or intranasal (IN) routes on amyloid-β (Aβ)-induced neuroinflammation and memory impairment in mice.

Experimental approach

Aβ_1-42 was injected into cerebral ventricles of adult CD1 mice. These mice received IL-17Ab via i.c.v. either at 1 h prior to Aβ_1-42 inje

SUBMITTER: Cristiano C 

PROVIDER: S-EPMC6715610 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature