Decellularized liver scaffolds promote liver regeneration after partial hepatectomy.

ABSTRACT: The resectable liver volume is strictly limited and this reduces the number of patients who may be treated. Recently, "tissue/organ decellularization", a new approach in bioengineering, has been investigated for its ability to produce a native organ scaffold by removing all the viable cells. Such a scaffold may support the repair of damaged or injured tissue. The purpose of this study was to evaluate the potential contribution of liver scaffolds to hepatic regeneration after hepatectomy. We sutured the partial liver scaffolds onto the surfaces of partially hepatectomized porcine livers and assessed their therapeutic potential by immune histological analysis at various time points. Animals were sacrificed after surgery and the implanted scaffolds were evaluated for the infiltration of vario

SUBMITTER: Shimoda H 

PROVIDER: S-EPMC6715632 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature